|
|
NADP+ + 17alpha-estradiol <=> NADPH + estrone + H+
|
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
K
|
| |
BRENDA:
BR29213
KEGG:
R02349
MetaCyc:
ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN
SABIO-RK:
2297
|
|
|
|
NAD+ + 17alpha-estradiol <=> NADH + estrone + H+
|
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
|
–
–
|
K
|
| |
BRENDA:
BR29213-a
KEGG:
R02347
MetaCyc:
ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN_WOP
|
|
|
|
17beta-estradiol + NADP+ <=> estrone + NADPH + H+
|
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
1.1.1.64
testosterone 17beta-dehydrogenase (NADP+)
|
–
–
–
–
–
–
–
|
MK
|
| |
BRENDA:
BR29326
KEGG:
R02353
MetaCyc:
ESTRADIOL-17-BETA-DEHYDROGENASE-RXN
SABIO-RK:
2301
|
|
|
|
17beta-estradiol + NAD+ <=> estrone + NADH + H+
|
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.300
NADP-retinol dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.53
3alpha(or 20beta)-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
–
|
K
|
| |
BRENDA:
BR29326-a
KEGG:
R02352
MetaCyc:
ESTRADIOL-17-BETA-DEHYDROGENASE-RXN_WOP
SABIO-RK:
2300
|
|
|
|
3''-phosphoadenylyl-sulfate + estrone <=> adenosine_3,5''-bisphosphate + Estrone_3-sulfate + H+
|
2.8.2.14
bile-salt sulfotransferase
2.8.2.15
steroid sulfotransferase
2.8.2.2
alcohol sulfotransferase
2.8.2.4
estrone sulfotransferase
|
–
–
–
–
|
K
|
| |
BRENDA:
BR48119
KEGG:
R02350
MetaCyc:
ESTRONE-SULFOTRANSFERASE-RXN
SABIO-RK:
2298
|
|
|
|
Estrone_3-sulfate + H2O <=> estrone + sulfate + H+
|
3.1.6.1
arylsulfatase
3.1.6.2
steryl-sulfatase
3.1.6.8
cerebroside-sulfatase
|
–
–
–
|
K
|
| |
BRENDA:
BS398868
KEGG:
R03980
MetaCyc:
RXN-14263
|
|
|
|
4-androstene-3,17-dione + 3 O2 + 3 reduced_flavodoxin <=> estrone + formate + 4 H2O + 3 flavin
|
1.14.14.14
aromatase
|
–
|
|
| |
BRENDA:
BR50746
KEGG:
R10515
|
|
|
|
19-oxoandrost-4-ene-3,17-dione + O2 + reduced_flavodoxin <=> estrone + formate + H2O + flavin
|
1.14.14.14
aromatase
|
–
|
K
|
| |
BRENDA:
BR50749;
BS425316
KEGG:
R02351
|
|
|
|
estrone + UDP-glucuronate <=> UDP + estrone_3-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
K
|
| |
BRENDA:
BS322194
KEGG:
R02358
|
|
|
|
estrone + H+ + O2 + NADH <=> 2-hydroxyestrone + NAD+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
| |
KEGG:
R02354
|
|
|
|
estrone + H+ + O2 + NADPH <=> 2-hydroxyestrone + NADP+ + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
| |
KEGG:
R02355
|
|
|
|
estrone + H+ + O2 + NADPH <=> 16alpha-hydroxyestrone + NADP+ + H2O
|
1.14.13
1.14.14.1
unspecific monooxygenase
|
–
–
|
K
|
| |
KEGG:
R02356
|
|
|
|
4-androstene-3,17-dione + reduced_[NADPH-hemoprotein_reductase] + O2 <=> estrone + oxidized_[NADPH-hemoprotein_reductase] + H2O + formate + H+
|
1.14.14.14
aromatase
|
–
|
|
| |
MetaCyc:
RXN-14746
|
|
|
|
19-oxoandrost-4-ene-3,17-dione + reduced_[NADPH-hemoprotein_reductase] + O2 <=> estrone + formate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
not assigned
|
–
|
M
|
| |
MetaCyc:
RXN66-346
|
|
|
|
4-androstene-3,17-dione + 3 O2 + 3 reduced_flavoproteins <=> estrone + formate + 4 H2O + 3 oxidized_flavoproteins
|
1.14.14.14
aromatase
|
–
|
|
| |
BRENDA:
BS424657
|
|
|
|
estrone + O2 <=> estra-1,5(10)-dien-3,17-dione + H2O2
|
1.1.3.6
cholesterol oxidase
|
–
|
|
| |
BRENDA:
BS373166
|
|
|
|
estrone_3-glucuronide + H2O <=> estrone + D-glucuronate
|
3.2.1.167
baicalin-beta-D-glucuronidase
|
–
|
|
| |
BRENDA:
BS431842
|
|
|
|
17beta-estradiol + NADH <=> estrone + NAD+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
| |
BRENDA:
BS257221-a
|
|
|
|
8-bromoadenosine_3''-phosphate_5''-phosphosulfate + estrone <=> 8-bromoadenosine_3'',5''-bisphosphate + Estrone_3-sulfate
|
2.8.2.4
estrone sulfotransferase
|
–
|
|
| |
BRENDA:
BS360462
|
|
|
|
formycin_3''-phosphate_5''-phosphosulfate + estrone <=> formycin_3'',5''-bisphosphate + Estrone_3-sulfate
|
2.8.2.4
estrone sulfotransferase
|
–
|
|
| |
BRENDA:
BS360463
|
|
|
|
tubercidin_3''-phosphate_5''-phosphosulfate + estrone <=> tubercidin_3'',5''-bisphosphate + Estrone_3-sulfate
|
2.8.2.4
estrone sulfotransferase
|
–
|
|
| |
BRENDA:
BS360461
|
|
|
|
Estrone_3-sulfate + phenol <=> estrone + phenyl_sulfate
|
2.8.2.22
aryl-sulfate sulfotransferase
|
–
|
|
| |
BRENDA:
BS360432
|
|
|
|
17beta-estradiol + NADPH <=> estrone + NADP+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
| |
BRENDA:
BS257221
|
|
|
|
UDP-glucose + estrone <=> UDP + estrone-3-beta-D-glucoside
|
2.4.1.173
sterol 3beta-glucosyltransferase
|
–
|
|
| |
BRENDA:
BS435964
|
|
|
|
3''-phosphoadenylyl_5''-phosphosulfate + estrone <=> adenosine_3'',5''-bisphosphate + estrone_7-sulfate
|
2.8.2.34
glycochenodeoxycholate sulfotransferase
|
–
|
|
| |
BRENDA:
BS375750
|
|
|
|
estrone_acetate + H2O <=> estrone + acetate
|
3.1.1.1
carboxylesterase
|
–
|
|
| |
BRENDA:
BS115431
|
|
|
|
4-nitrophenyl_sulfate + estrone <=> 4-nitrophenol + Estrone_3-sulfate
|
2.8.2.22
aryl-sulfate sulfotransferase
|
–
|
|
| |
BRENDA:
BS425754
|
|
|
|
ATP + H2O + estrone <=> ADP + phosphate + estrone
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
| |
BRENDA:
BS445011
|
|
|
|
estrone-3-beta-D-glucoside + H2O <=> beta-D-glucose + estrone
|
3.2.1.21
beta-glucosidase
|
–
|
|
| |
BRENDA:
BS214493
|
|
|
|
H+ + 4-androstene-3,17-dione + NADPH + O2 <=> NADP+ + formate + estrone + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
|
| |
SABIO-RK:
9576
|
|
